Trop Team
Search Harland trop site
Obtain Embryos
Genomic Resources
Trop Labs

Mutants

In our genetic screen, we have identified a number of potential mutants with interesting phenotypes. Images of the mutants are listed below along with a preliminary designation of the mutation. Many of these mutants are preliminary and need to be confirmed in subsequent generations.

There are a few mutations that have been discovered in the background of the inbred strains. We have identified these mutations over and over again in multiple different animals. Complementation testing has shown that each of these phenotypes isolated in different founders occurs at the same locus.

We have chategorized the mutations into a few groups. Confirmed mutants have been passed through at least one generation. Potential mutations have been seen in at least one mating. Typically that mating is repeated and then if seen, evaluated in the next generation. If the mutations is present in the next generation, it becomes confirmed. Background mutants are present in multiple founders or in animals that have not been exposed to mutagenesis.


Background Mutations

Mutant
Phenotype

grinch: confirmed background mutation possibly in lymphatic development

bubblehead: confirmed background mutation in craniofacial development

curly: confirmed background mutation in cell proliferation/survival

bub2: confirmed background mutation in craniofacial development

loris: confirmed background mutation in craniofacial and eye development

jawbreaker: confirmed background mutation in craniofacial development

beaver: confirmed background mutation in embryo viability

rubenesque: confirmed mutation in pigmentation, cardiovascular function and cell migration

[Picture shows a double grinch and ruby. Ruby embryos is in the middle]



Induced Mutations

dexter: potential background mutation in left:right patterning

owl: confirmed mutation in craniofacial development

[Picture shows a grinch embryo in the middle and owl embryo at the bottom]

hourglass: confirmed mutation in eye development

blind ambition: potential mutation in dorsoventral development

juanito: potential mutation in melanocyte and gut development

clearview: potential mutation in melanocyte development

undulated: potential mutation in dorsoventral development